Several new strategies are under investigation for vaccines, monoclonal antibodies, and serological tests with improved specificity, including multiplex and point-of-care diagnostics. This is a phase 1 trial, consisting of an initial open-label sentinel run-in (n=25) phase and a randomized, double-blind, dose-finding trial (n=125) in flavivirus naïve adults aged 18 to 49 years. In total …

The randomized controlled phase 1 trial, vla1601-102, enrolled …