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Review recommended orserdu® dosing, and while rare, how to make any dose modifications necessary for esr1-mutated, er+/her2- mbc patients. A phase 1b/2 study of palazestrant (op-1250), an oral complete estrogen receptor antagonist (ceran) and selective er degrader (serd), with palbociclib in er-positive, her2-negative, … Novel oral serds and other next-generation ets are in clinical development for er+ breast cancer as single agents and in combination with established targeted therapies.