Since dapagliflozin leads to heavy glycosuria (sometimes up to about 70 grams per day), it can lead to rapid weight loss and tiredness. The glucose acts as an osmotic diuretic (this effect is the cause of … By completing this registration, you are confirming that you are at least 18 years old, are a resident of the us, and would like to receive information in the future about farxiga and related health …