The meaning of lose is to miss from one's possession or from a customary or supposed place. How to use lose in a sentence. If you lose something, you do not know where it is, for example, because you have forgotten where you put it.

If you have nothing (else/left) to lose, you cannot make a situation worse by taking a risk. If you have a lot to lose or have too much to lose, you could make your situation much worse by taking a risk or … To come to be without (something in one's possession or care), through accident, theft, etc. , so that there is little or no prospect of recovery. See examples of lose used in a sentence.