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An elevated ldl-cholesterol is a potent risk factor for atherosclerotic cardiovascular disease (ascvd). Invariably, pharmacotherapy is required to get high risk patients to goal. The cornerstone of such Γ’β¬Β¦
Key points bempedoic acid is a novel lipid-lowering therapy that inhibits adenosine triphosphate (atp)-citrate lyases and has been shown to decrease low-density lipoprotein cholesterol (ldl-c) by Γ’β¬Β¦ Bempedoic acid is a new treatment for high cholesterol. It can be used when statins are not suitable and ezetimibe is not working well enough on its own. Bempedoic acid (ba) is a novel oral anti-cholesterol drug that can be taken once a day. 7, 8 by inhibiting cholesterol synthesis, ba indirectly upregulates hepatic ldl uptake receptors, leading to Γ’β¬Β¦ Ezetimibe reduces cholesterol absorption and interrupts enterohepatic cholesterol recirculation. Bempedoic acid, a prodrug activated in the liver, lowers ldl and apob through hepatic-specific
7, 8 by inhibiting cholesterol synthesis, ba indirectly upregulates hepatic ldl uptake receptors, leading to Γ’β¬Β¦ Ezetimibe reduces cholesterol absorption and interrupts enterohepatic cholesterol recirculation. Bempedoic acid, a prodrug activated in the liver, lowers ldl and apob through hepatic-specific