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They make the point that studies on beta blockade have distinguished fatigue from depression, have highlighted that there does not seem to be a temporal association between beta-blocker use and … Dallas, march 15, 2021 †beta-blockers treat various cardiovascular diseases and were not more likely to cause depression compared to other similar treatments, according to new research … Abstract introduction depression is a commonly cited adverse efect of î²-blockers but the evidence for a causal relationship is limited.